We have already published an article about famous people who suffer from Heterochromia Iridium, a rare condition characterized by a difference in coloration of the iris caused by relative excess or lack of melanin. But in fact, there are many more bizarre genetic anomalies and medical conditions that people have to deal with. From the stone man syndrome to cyclopia, check out these 25 of them.
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Nipple on a foot

Having extra nipples is not as unusual as it may sound but a full-sized nipple on the sole of a foot is extremely unusual. According to the California-based Dermatology Journal, it is the first time a nipple has ever been discovered so far down somebody’s body. The proud “owner” of this primacy is 26-year-old Lily Allen from Brazil.
Three legs

Born in Sicily, Italy, Frank Lentini (1881 – 1966) was known for having three legs. His deformity was the result of a partially absorbed conjoined twin. The twin was attached to his at the base of his spine and consisted of a pelvis bone, a rudimentary set of male genitalia and a full-sized leg extending from the right side of his body, with a small foot attached to this extra knee. It is recorded that Lentini had 16 toes in total and 2 sets of functioning male sexual organs
Gigantic hand

Officially called macrodactyly, local gigantism is a rare medical condition, in which a certain part of the body grows to a larger than normal size. In 2007, Lui Hua from China was hospitalized with this condition. At that time, his left thumb measured over 10 inches (25.4 cm) and his index finger almost reached 12 inches (30.5 cm).
Progressive Lipodystrophy

Also known as reverse Benjamin Button syndrome, lipodystrophy makes sufferers look much older than they really are. So far, only about 200 cases of this bizarre condition have been reported worldwide, mainly affecting women. One of them was Zara Hartshorn, a teenage girl from South Yorkshire, UK, who – at the age of 15 – was sometimes mistaken for the mother of her older sister.
The Elephant Man

Joseph Merrick (1862 – 1890) was an Englishman who, due to his genetic anomalies, was nicknamed The Elephant Man. His skin appeared thick and lumpy, he developed an enlargement of his lips, and a bony lump grew on his forehead. The exact cause of these anomalies is unknown, however, modern doctors suggest it was a combination of several diseases such as neurofibromatosis type I and Proteus syndrome.